Effect of polyenic antibiotics on Ehrlich ascites and Novikoff hepatoma cells.
نویسندگان
چکیده
The incorporation of thymidine in Novikoff hepatoma cells and Ehrlich ascites cells was severely and irreversibly inhibited by the polyenic antibiotics filipin and lucensomycin, known for their action on phospholipid-cholesterol membranes. No inhibition could be shown on regenerating liver cells or on acellular preparations from tumor cells. Despite the well-known site of action of these antibiotics on cell membranes, which was ascertained by s ' Cr efflux, transcellular migration of glutamate-14 C through neoplastic
منابع مشابه
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ورودعنوان ژورنال:
- Cancer research
دوره 31 5 شماره
صفحات -
تاریخ انتشار 1971